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Laboratory of Polymers & Biomaterials

Institute of Fundamental Technological Research

  • 1 Oliwia Jeznach as a laureate of the Kosciuszko Foundation scholarship

    It is our pleasure to inform you that our team member, Mrs. Oliwia Jeznach has become one of the laureate of scholarship granted by the Kosciuszko Foundation. Congratulations Oliwia!
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  • 2 Professor dr hab. Andrzej Ziabicki

    We announce with very deep regret that on March 14th, 2019 left us our great Master and Teacher - Professor dr hab. Andrzej Ziabicki.
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  • 3 New internschip students in our laboratory!

    As every year new internship students will join our research team! To get know who will join us this summer please see in the link below...
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  • 4 Polish-Israeli Conference on Electrospinning and Tissue Engineering

    It is our great pleasure to announce the 1st Polish-Israeli Conference on Electrospinning and Tissue Engineering (PICETE 2018), which will be held on 4-5th October 2018 in Warsaw, Poland, at the Institute of Fundamental Technological Research, Polish Academy of Sciences.Kindly visit the PICETE2018 conference website.
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  • 5 New OPUS and PRELUDIUM grant in our laboratory!

    We would like to inform that National Centre of Science granted the project of our laboratory leader, prof. Paweł Sajkiewicz and our colleague, Piotr Denis, M.Sc., in OPUS and PRELUDIUM program, respectively. Both, projects were subbmited in the ST8 category - Process and production engineering. Congratulations for the project leaders!
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Source of Founding: Polish National Science Center (NCN), PRELUDIUM grant

Duration: 3 years

Manager/ Principal Investigator: Judyta Dulnik, M.Sc.

Aims

The main objective of the project is to determine the optimal method of crosslinking of the polycaprolactone nanofibers with the addition of gelatin electrospun from alternative solvents for use of this type of biomaterials in tissue engineering. Pursuing this goal will enable the broadening of knowledge on the effect of crosslinking on the structure and properties of complex material systems, such as bicomponent nanofibres PCL/gelatin from alternative solvents.

Abstract

Application of mixture of acetic acid and formic acid as a solvent, reduces production cost and eliminates the use of highly toxic perfluorinated alcohols such as 1,1,1,3,3,3-hexafluoro-2-propanol and 2,2,2-trifluoroethanol, however, the structure of polymer solution becomes noticeably emulsive (project OPUS). This results in non-uniform distribution of individual components in the fibre, what as it has been confirmed by preliminary biodegradation study induces faster leaching of gelatin from fibres in an environment of a living organism. The need to stabilize gelatin in bicomponent fibres requires the use of proper crosslinking agent. Systematic studies on crosslinked nanofibres made from polycaprolactone and gelatin will determine the most effective crosslinking conditions, what will enable the process of gelatin leaching to slow down. This will ensure good functioning of the biomaterial in its destination site, by maintaining its initial material properties, throughout a long time perspective. The studies of crosslinking process will also help improve, as well as optimize material’s mechanical properties for medical purposes.

Significance of the project for science/ Motivation

The main outcome of the project will be determination of the optimal method of crosslinking bicomponent PCL/gelatin nanofibers electrospun from alternative solvents, from the perspective of the use of this type of material in tissue engineering. The results of the project will solve a serious problem occurring in this material system, which is the loss of biopolymer (gelatin) in an environment of a living organism. In the case of bicomponent fibers from alternative solvents, there are no articles describing an effect of crosslinking conditions on the rate of degradation of the gelatin. Considering bicomponent nanofibers, there can be found very little information about attempts of their crosslinking. Because of the unquestionable advantages of the use of cheaper, non-toxic solvents for electrospinning of bicomponent fibers with an addition of gelatin, work in this area is necessary for the progress of tissue engineering. Expected results of the experiments scheduled in the project are intended to provide medicine with new type of scaffold material whose functionality exceeds any of the currently available on the market.

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