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Laboratory of Polymers & Biomaterials

Institute of Fundamental Technological Research

  • 1 Oliwia Jeznach as a laureate of the Kosciuszko Foundation scholarship

    It is our pleasure to inform you that our team member, Mrs. Oliwia Jeznach has become one of the laureate of scholarship granted by the Kosciuszko Foundation. Congratulations Oliwia!
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  • 2 Professor dr hab. Andrzej Ziabicki

    We announce with very deep regret that on March 14th, 2019 left us our great Master and Teacher - Professor dr hab. Andrzej Ziabicki.
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  • 3 New internschip students in our laboratory!

    As every year new internship students will join our research team! To get know who will join us this summer please see in the link below...
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  • 4 Polish-Israeli Conference on Electrospinning and Tissue Engineering

    It is our great pleasure to announce the 1st Polish-Israeli Conference on Electrospinning and Tissue Engineering (PICETE 2018), which will be held on 4-5th October 2018 in Warsaw, Poland, at the Institute of Fundamental Technological Research, Polish Academy of Sciences.Kindly visit the PICETE2018 conference website.
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  • 5 New OPUS and PRELUDIUM grant in our laboratory!

    We would like to inform that National Centre of Science granted the project of our laboratory leader, prof. Paweł Sajkiewicz and our colleague, Piotr Denis, M.Sc., in OPUS and PRELUDIUM program, respectively. Both, projects were subbmited in the ST8 category - Process and production engineering. Congratulations for the project leaders!
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Source of Founding: National Science Centre, PRELUDIUM program, VIII edition

Duration: July 2015 – March 2018

Manager/ Principal Investigator: Olga Urbanek, M.Sc.

Supervisor: Prof. Paweł Łukasz Sajkiewicz, Ph.D.

Participants: Filippo Pierini

Aims

Project is mainly focused on influence of electrospinning parameters on chemical composition of nanofibers surface and its effect on efficiency of further surface modification. The main aim of the project is surface modification of the bicomponent nanofibers with chosen polycation. Characteristics of selected properties, both modified and not modified nonwoven, will be conducted. In particular its surface features will be characterized. An additional aim of the study is to determine the effect of surface modified nonwoven on the cell activity, morphology and proliferation in in vitro conditions. Moreover, we will try to determine the optimum composition of nonwovens from the view point of effective surface modification and cell response.

Abstract

The polymers chosen for fibers formation are commonly used in tissue engineering as scaffolds for skin, nerve or cartilage regeneration. Natural polymer addition increases hydrophilicity and biocompatibility of the material. Also its structure is highly similar to GAG-natural component of cartilage. Synthetic polymer will increase its mechanical properties. Moreover, nanofibers structure is highly similar to ECM components, what additionally may have positive effect on cell response. Biomimetic approach to modify the surface of nanofibers will allow to create complex which naturally occurre in the cartilage. Presence of this complex in the scaffold for cartilage regeneration will allow to control water content in tissue volume, what is the most important for diffusion of nutrients, metabolites and chondrocytes life and activity in cartilage.

Significance of the project/ Motivation

The research planned in this project would contribute the development of science on biomimetic scaffolds made by electrospinning method from polymer blends modified with polycation, naturally occurring in the human tissue. Fundamental research will determine whether the scaffold which was designed is suitable in structure (nanofiber) and chemical composition for the activity and proliferation of chondrocytes. Answers to questions arising from the assumptions of the project at a later term, would contribute to the development of a new medical device used in the cartilage reconstruction.

Articles published in the frame of the project

Urbanek O, Sajkiewicz P, Pierini F. (2017). The effect of polarity in the electrospinning process on PCL/chitosan nanofibres’ structure, properties and efficiency of surface modification. Polymer 124 : 168-175

Urbanek O, Sajkiewicz P, Pierini F, Czerkies M, Kołbuk D, (2017). Structure and properties of polycaprolactone/chitosan nonwovens tailored by solvent systems. Biomedical Materials, 12(1), 015020

 

 

 

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